金葡素注射液治疗恶性胸腔积液的疗效、预后及对患者免疫系统的作用
2020-05-22 15:13:46
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金葡素注射液治疗恶性胸腔积液的疗效、预后及对患者免疫系统的作用
Effect of staphylotoxoid injection on the curative,prognosis and immune system in malignant pleural effusion摘要目的研究金葡素注射液治疗恶性胸腔积液的疗效、预后及其对免疫系统的作用。方法选取丽水市中心医院2012年8月-2014年11月收治的恶性胸腔积液患者65例,根据治疗方法分为观察组33例与对照组32例,2组均实施胸腔闭式引流术使胸腔积液引流完全。观察组引流完全后予以金葡素注射液2 500 U腔内注射,对照组予以传统方法博来霉素1 mg/kg腔内注射。比较2组疗效、预后及对免疫系统的作用。结果观察组总有效率为72.7%,显著高于对照组的43.8%（P〈0.05）;不良反应率低于对照组,中位生存期长于对照组,白细胞水平较对照组明显升高（P〈0.05）。结论金葡素注射液治疗恶性胸腔积液对比传统方法博来霉素胸腔内注射,能更有效控制病情,减少不良反应,同时能提高其免疫能力,改善机体耐受能力。Objective To study the curative effect and prognosis of malignant pleural effusion treated by staphylotoxoid injection and its effect on immune system. Methods A total of 65 patients with malignant pleural effusion from August 2012 to 2014 November in Lishui City Central Hospital were selected,and divided into observation group（ n = 33） and control group（ n = 32） in terms of different treating methods,two groups were implemented with thoracic closed drainage to drain pleural effusion up. The observation group was completely drained after 2 500 U intrapleural injection of staphylotoxoid injection,the control group to the traditonal method of bleomycin 1 mg/kg injection. The efficacy,prognosis and immune system were compared. Results The effective of rate of the observation group was significantly higher（ 72. 7%） than the control group（ 43. 8%）; the adverse reaction rate of observation group was lower and its median survival time was longer; white blood cells counts of observation group was significantly more than control group（ P〈0. 05）. Conclusion Compared with the traditional method of bleomycin intrapleural injection treatment of malignant pleural effusion,staphylotoxoid injection can be more effective control of the disease,reduce adverse reactions,and can improve their immunity and improve the body tolerance.
基金丽水市公益性技术应用项目(2013JYZB34)
金葡素注射液治疗恶性胸腔积液的疗效、预后及对患者免疫系统的作用 .pdf